看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。* W" f1 Y5 a6 a! W! g, M* H9 e
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Currently available feasibility data for possible combination strategies. 5 \- L9 R# w$ d- P
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Combination Feasibility according to preliminary data
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. }! P" K# p& L! ^Bevacizumab + sorafenib Yes, reduced dose 8 A& \8 F" M+ w3 _. l. t
Bevacizumab + sunitinib† No & I" F: N B: l9 I- G" j( k7 T
Bevacizumab + temsirolimus Yes
" C; ^$ J; A6 C f* OBevacizumab + everolimus Yes ' e A) f) a2 Z2 i0 O
Sorafenib + sunitinib ?
1 I3 o! b) r! U) D5 {' ~Sorafenib + temsirolimus Yes, reduced dose 5 U5 v6 K! I8 [2 b: O! {
Sorafenib + everolimus Yes, reduced dose : `; [ S( N% L$ g8 x5 h
Sunitinib + temsirolimus† No . V, H8 \: `! ]* I% l
Sunitinib + everolimus ? & p1 u5 G8 o% h- W- m
Temsirolimus + everolimus ?
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4 L2 T ~/ [ o; D†Led to US FDA warning. Y$ D8 i( i# q7 A
?: As yet unattempted combination.( A- d' D( c3 Y4 r! ]/ _1 x
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